release can be delayed from 1 to 10 hours, depending on permeability of the rate-controlling membrane and the size of placebo. The results of ivivc ( fig. (1) Semipermeable Membrane Since the membrane in osmotic systems is semipermeable in nature, any polymer that is permeable to water but impermeable to solute can be selected. Reni and coworkers investigated the usefulness of cisplatin, epirubicin and 5FU in combination with gemcitabine, the combination therapy was called pefg. This needed pumps to be stored empty and water to be loaded prior to use. A combination therapy comprising of oxiplatin, irinotecan, leucovorin followed by 5 FU (folfirinox) has also been tested against gemcitabine.
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The QC samples were divided into.1 ml al" in centrifuge tubes and stored at -70o before use. The organic layer was transferred to a 10 ml centrifuged tube and evaporated to dryness under stream of dry nitrogen at 37o. The surfactants act by regulating the surface energy of materials to improve their blending into the composite and maintain their integrity in the environment of use during the drug release period. R2.9873 from linear line obtained when release rate was plotted against osmotic pressure difference (osmotic pressure inside the formulation was found to.369 mm Hg) shown in fig. Figure 2: Rose Nelson Pump. Drug release rate from cpop depends on various factors like coating thickness, solubility of drug in tablet core, level of leachable pore-forming agent(s) and the osmotic pressure difference across the membrane 54,. This observation could be attributed to the fact that as the drug releases at a rate that exceeds the rate of absorption; it leads not only to side effects but also to first pass metabolism.
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